There are different psychoactive compounds with which microdoses are usually made , among the most common are psilocybin from hallucinogenic mushrooms, mescaline from peyote cactus and lysergic acid ( lysergic acid diethylamide), better known as LSD.
Our microdoses are made from Psilocybe mushrooms, however LSD is also common and probably started microdosing as we now know it. So in this article we want to tell you a little more about the fascinating history of this compound and its therapeutic applications.
a funny accident
Lysergic acid, or LSD, was synthesized by Swiss chemist Albert Hofmann in 1938 while he was investigating a compound derived from the ergos fungus that is commonly found in various grains such as wheat. Hofmann worked at the Swiss pharmaceutical company Sandoz and his goal was to synthesize a compound to treat postpartum hemorrhage and circulation problems, but as you can imagine, he ended up with something else entirely.
For a few years, tests were done with this new compound, but none showed the results he was looking for. It was not until 10 years later, while he was synthesizing this molecule again, that the substance came into contact with his skin and minutes later he felt "strange" and observed small changes in his perception of his environment, but without much intensity. That was the first trip on this substance and the only one that has been completely accidental since then.
Three days later, like a good scientist, he decided to test this compound again by consuming an amount of 250 micrograms, for what is now considered a very large dose. It was then that on April 19, 1948, the first acid trip took place and would change the history of psychoactive substances forever.
During his experiment, Hofmann noticed many fractals in his vision and unexpected things. While returning home on his bicycle, he learned about the scope of this new substance, which is why this date is now known as "Bicycle Day".
The next day, Hofmann felt very calm and very clear about things, so he continued his study and a few years later, the pharmaceutical company Sandoz began to market this new substance named LSD-25 under the name "Delisid " . initially supplying various psychiatric institutes.
From the legal to the illegal
For almost two decades, the effects and benefits of LSD were widely studied in the scientific community, there was great potential for the treatment of depression, anxiety, schizophrenia and addictions. However, curiosity about its psychoactive effects appealed to the general public and inevitably this substance ended up in unsupervised and recreational use.
In many ways LSD was a catalyst for the counterculture, for the hippie movement; and to which this substance is mostly associated today. This movement created a change in the collective consciousness and provoked social discontent towards the United States government in the context of the war with Vietnam.
After a few years of protests and disagreements, along with unregulated use of LSD, the US government decided to ban this substance in 1968 and took it upon itself to demonize it with disinformation campaigns, thus generating the stigma associated with LSD that endured in society. for the next decades.
This caused the study and exploration of this psychiatric tool to stop, as well as that of other psychedelic substances such as psilocybin and mescaline, and from then on it was consumed only in recreational contexts and illegally.
the third wave
In recent years there has been a resurgence of scientific interest in psychedelic substances and their possible applications. Every day more researchers and universities around the world show interest in the rigorous study of psychedelics such as LSD and psilocybin to understand the mind and to treat different psychological disorders. They have resumed the investigations of the past decades and have been in charge of demystifying the taboos created around it; They have shown that they are not addictive substances nor do they present any type of health risk.
It has been found to be an effective tool, under the right context and guidance, to effectively treat addictions, depression, post-traumatic stress, and other mental disorders. Great benefits have also been seen in the microdosing protocol with LSD and psilocybin. In Silicon Valley, the use of microdosing to increase creativity and productivity is becoming more common.
Unfortunately, given the current legal status of this substance, the challenge of finding the pure substance remains.
Although the effects of psilocybin and LSD are very similar, they can vary from person to person, depending on personality, "set & setting", intention and dosage.
If you are interested in trying a psilocybin microdose treatment to witness the benefits, you can get your PrajnaDose here .
Fuentes et al. (2020) “Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials” https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00943/full
- Huten et al . (2019). “ Motives and Side-Effects of Microdosing With Psychedelics Among Users” https://academic.oup.com/ijnp/article/22/7/426/5509881?login=true
- Stamets et al. (2021) “ Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers” https://www.nature.com/articles/s41598-021-01811-4
- History: LSD https://www.history.com/topics/crime/history-of-lsd
- Dyck (2015) “LSD: a new treatment emerging from the past” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592308/